2005 Jul 29; 280(30):27879-87. Medicina (Kaunas). J Biol Chem. 2021 11; 25(11):2149-2159. He did not respond to inewsource s interview request. 2010 Jul-Aug; 19(4):311-20. 2011 Jan; 53(1):4-6. 1999 Aug; 21(2):238-45. People who share similar concepts with this person. 1998 Sep; 13 Suppl:S39-50. Am J Gastroenterol. 2000 Dec; 279(6):G1333-42. DNA-mediated gene transfer into adult rat hepatocytes in primary culture. Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. 1994 Sep; 14 (9):5950-60. Insulin-like growth factor-I and epidermal growth factor interact to regulate growth and gene expression in IEC-6 intestinal epithelial cells. 1991 Jun; 87(6):2230-5. Gut. Liver Transpl. Hepatol Res. 2020; 15(3):e0229445. HBO Special recorded in Las 2005 Feb; 115(2):209-18. Gastroenterology. 2008 Sep; 5(9):496-7. 2019 10; 68(10):1884-1892. Confocal microscopy of the mitochondrial permeability transition in necrotic and apoptotic cell death. Hepatology. Next-generation academic medicine. Decreasing fibrogenesis: an immunohistochemical study of paired liver biopsies following lamivudine therapy for chronic hepatitis B. J Hepatol. 2000 Feb; 88(2):142-9. Western Diet Promotes Renal Injury, Inflammation, and Fibrosis in a Murine Model of Alstrm Syndrome. 2014 Mar 07; 289(10):7082-7091. Gastroenterology. Gastroenterology. 2007 Nov; 46(5):1443-52. J Biol Chem. What goes up must come down: the emerging role of microRNA in fibrosis. Mol Endocrinol. Bataller R, Schwabe RF, Choi YH, Yang L, Paik YH, Lindquist J, Qian T, Schoonhoven R, Hagedorn CH, Lemasters JJ. Gastroenterology. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. J Clin Invest. J Biol Chem. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. Derived automatically from this person's publications. 1987 Sep; 79(3):449-56. Jobin C, Bradham CA, Russo MP, Juma B, Narula AS. 2002 Sep; 123(3):877-8. 1995 Sep 29; 270(39):22689-92. Am J Physiol. Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury. Floch MH, Walker WA, Sanders ME, Nieuwdorp M, Kim AS. Sanz S, Pucilowska JB, Liu S, Rodrguez-Ortigosa CM, Lund PK. Download Bio Dr. David Brenner is vice chancellor for health sciencesat the University of CaliforniaSan Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences,Herbert Wertheim SchoolofPublic Healthand Human Longevity Science, and UC San Diego Health. Front Mol Biosci. 2020 Nov 03; 32(5):901. 2012; 5(Suppl 1):S17. 1998 Feb 15; 101(4):802-11. Harada N, Hatano E, Koizumi N, Nitta T, Yoshida M, Yamamoto N. c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. Patel NS, Hooker J, Gonzalez M, Bhatt A, Nguyen P, Ramirez K. The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis. Am J Pathol. 1995 Sep; 9(9):1157-65. Report of the American Gastroenterological Association (AGA) Institute Obesity Task Force. 2006 Sep; 131(3):957-60. Cell Metab. Gastroenterology. 2006 Nov; 26(9):1138-47. Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts. Nat Rev Gastroenterol Hepatol. 2015 Jan; 22(1):164-73. 1993 Jan; 17(1):164-6. 2012 Mar; 27 Suppl 2:65-8. 2004 Apr; 18(6):720-2. NK and NKT cells in liver injury and fibrosis. 2016 Aug; 38(4):291-302. TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells. Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex. 2014 Aug; 124(8):3566-78. 1998 10; 275(4):C1058-66. Am J Physiol Cell Physiol. Gut. Science. Bradham CA, Qian T, Streetz K, Trautwein C. NF-kappaB inactivation converts a hepatocyte cell line TNF-alpha response from proliferation to apoptosis. NEK1 mutations in familial amyotrophic lateral sclerosis. 1995 Oct; 6(10):1285-90. Nat Commun. Nature. Introducing PNAS Nexus. 1999 Nov; 20(11):2095-100. 2004 Jun; 135(6):619-28. Int J Biochem Cell Biol. Transforming growth factor-alpha stimulates proto-oncogene c-jun expression and a mitogenic program in primary cultures of adult rat hepatocytes. Hepatology. JCI Insight. Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury. Liedtke C, Plmpe J, Kubicka S, Bradham CA, Manns MP. A method for in vitro DNase I footprinting analysis on supercoiled templates. 1992 Jul-Aug; 11(6):443-52. Differential expression of human lysyl hydroxylase genes, lysine hydroxylation, and cross-linking of type I collagen during osteoblastic differentiation in vitro. Mol Cell Biol. 2005 Jun; 42(6):850-9. The mitochondrial permeability transition augments Fas-induced apoptosis in mouse hepatocytes. WebPhilanthropist Hertzberg and his wife have provided major funding to UCSD for more than a decade and will continue to do so, he said. Gastroenterology. 2008 Feb; 47(2):677-85. Cell Metab. Xu Y, Bialik S, Jones BE, Iimuro Y, Kitsis RN, Srinivasan A. Porphyrias. 2007 Apr-Jun; 6(2):83-8. Gene expression profiles during hepatic stellate cell activation in culture and in vivo. J Biol Chem. Modlin IM, Adler G, Alexander K, Arnold R. Liver fibrosis. Adler DH, Phillips JA, Cogan JD, Iverson TM, Schnetz-Boutaud N, Stein JA. Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells. Circulation. J Hepatol. Hepatology. Techniques to measure nucleic acid-protein binding and specificity. Liver Transpl Surg. Expression of collagen genes in the liver. 1994 Oct; 267(4 Pt 1):G552-61. 2003 Jan 10; 278(2):927-33. Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation. David Brenners wife Amber confirmed her husbands passing on Friday, with fans curious to 2016 08; 65(2):369-76. The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo. Hepatology. 2022 08 02; 34(8):1201-1213.e5. 2010 Oct; 52(4):1420-30. 1988 Apr 15; 48(8):2288-91. 2012 Mar; 10(3):285-90.e1. 2020; 2(2):fcaa133. Schnabl B, Purbeck CA, Choi YH, Hagedorn CH. Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. J Hepatol. 2004 Nov; 40(5):1106-15. The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Meurer SK, Alsamman M, Sahin H, Wasmuth HE. 1989 Aug 11; 17(15):6055-64. L-glutamine and L-asparagine stimulate ODC activity and proliferation in a porcine jejunal enterocyte line. Gastroenterology. J Hepatol. Hepatology. 2005 Apr; 115(4):849-59. NADPH oxidase mediated oxidative stress in hepatic fibrogenesis. 2000 Jan; 48(1):39-44. Bcker U, Schottelius A, Watson JM, Holt L, Licato LL. Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice. Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. Clin Gastroenterol Hepatol. The origin of myofibroblasts in liver fibrosis. Meng F, Wang J, Ge J, Fan X, Wang B, Han L. Innate immunity in alcoholic liver disease. Biofactors. 1993 Sep; 92(3):1336-48. J Biol Chem. 2007 Jun; 22 Suppl 1:S73-8. Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R. Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. Regulation of alpha1(I) collagen messenger RNA decay by interactions with alphaCP at the 3'-untranslated region. Posttranscriptional regulation of collagen alpha1(I) mRNA in hepatic stellate cells. Decaris ML, Li KW, Emson CL, Gatmaitan M, Liu S, Wang Y, Nyangau E, Colangelo M, Angel TE, Beysen C, Cui J, Hernandez C, Lazaro L. Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease. Am J Physiol. 2015 Apr; 61(4):1239-50. Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice. Nucleic Acids Res. Kodama Y, Taura K, Miura K, Schnabl B, Osawa Y. Molecular pathogenesis of liver fibrosis. Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the Union-Tribune, Were glad theres been a settlement. Semaphorin 7A contributes to TGF--mediated liver fibrogenesis. 2016; 7:17. 2001 Jul 01; 167(1):173-80. AIDS. Mixed-methods quantitative-qualitative study of 29 nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits. 2004 Nov; 40(5):1151-9. 1993 Apr; 264(4 Pt 1):G589-95. Ferrochelatase cDNA delivered by adenoviral vector corrects biochemical defect in protoporphyric cells. J Clin Invest. Clin Gastroenterol Hepatol. 1997 Jan 17; 272(3):1753-60. Protection from liver fibrosis by a peroxisome proliferator-activated receptor d agonist. Nat Rev Gastroenterol Hepatol. 2017 May 02; 25(5):1054-1062.e5. 1994 Jul 29; 269(30):19203-6. He will assume his new role effective September 14. Am J Physiol Gastrointest Liver Physiol. 2009; 44 Suppl 19:1-7. Development of a new, simple rat model of early alcohol-induced liver injury based on sensitization of Kupffer cells. J Gastroenterol Hepatol. 2007 Aug; 22(8):1256-64. Hepatology. Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. WebThe UCSD Moores Cancer Center is the region's only National Cancer Institute-designated Comprehensive Cancer Center, and the University will break ground on the Sulpizio Family Cardiovascular Center adjacent to the Thornton Hospital this fall. 2021 08 01; 321(2):H435-H445. Am J Physiol. 2013 Sep 16; 202(6):951-66. Curr Pathobiol Rep. 2013 Sep; 1(3):209-214. Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells. J Hum Nutr Diet. Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice. Cell Death Differ. 2014 Apr 29; 63(16):1626-33. 2014 Jul 21; 5:4451. In Vitro Cell Dev Biol. Note that an individual publication can be assigned to more than one field. Yang L, Magness ST, Bataller R, Rippe RA. Quadruple genetic variants in a sporadic ALS patient. Gratte FD, Pasic S, Abu Bakar NDB, Gogoi-Tiwari J, Liu X, Carlessi R. The genetic landscape of axonal neuropathies in the middle-aged and elderly: Focus on MME. 2013 02 15; 177(4):333-42. Gastroenterology. 2019 01; 49(2):183-193. Hepatology. Molecular epidemiology and cancer prevention. 2011 Mar 11; 286(10):8609-8619. Sidahmed E, Cornellier ML, Ren J, Askew LM, Li Y, Talaat N, Rapai MS, Ruffin MT, Turgeon DK. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Gastroenterology. Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease. 2015 Jul; 22(7):512-8. Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin. Dominant-negative TAK1 induces c-Myc and G(0) exit in liver. Mutation of the 5'-untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice. Cell Metab. Yan AW, Fouts DE, Brandl J, St?rkel P, Torralba M, Schott E. Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. Hepatic stellate cells and the reversal of fibrosis. Hepatology. Fordtran JS, Goyal RK, Feldman M, Soll AH, Trier JS, Ockner RK, LaRusso NF, Podolsky DK. 2005 May; 41(5):1046-55. 2008 Aug; 42(5):349-61. 2008 Jul; 255(7):993-1000. Reif S, Lang A, Lindquist JN, Yata Y, Gabele E, Scanga A. TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells. People in Profiles who have published with this person. Gastroenterology. 2018 12; 16(12):1974-1982.e7. Nuclear factor-kappaB in the liver: friend or foe? Exp Biol Med (Maywood). 2000; 32(1 Suppl):32-8. 1999 Mar; 15(2):103-7. 2017 01; 65(1):78-88. Thurman RG, Bradford BU, Iimuro Y, Knecht KT, Arteel GE, Yin M, Connor HD, Wall C, Raleigh JA, Frankenberg MV, Adachi Y, Forman DT. Iwaisako K, Haimerl M, Paik YH, Taura K, Kodama Y. Hepatology. 2016 05; 139(Pt 5):e28. J Biol Chem. Diehl AM, Yin M, Fleckenstein J, Yang SQ, Lin HZ. Gastroenterology. 2017 12 12; 8(1):2137. 2010 Mar; 51(3):942-52. Bataller R, Gbele E, Parsons CJ, Morris T, Yang L, Schoonhoven R. Anandamide induces necrosis in primary hepatic stellate cells. J Biol Chem. Cellular differentiation causes a selective down-regulation of interleukin (IL)-1beta-mediated NF-kappaB activation and IL-8 gene expression in intestinal epithelial cells. Molecular defects in ferrochelatase in patients with protoporphyria requiring liver transplantation. Heterogeneity of HSCs in a Mouse Model of NASH. Hepatology. Lab Invest. Ascorbic acid stimulation of collagen biosynthesis independent of hydroxylation. Paik YH, Schwabe RF, Bataller R, Russo MP, Jobin C. Expression of the NF-kappa B target gene X-ray-inducible immediate early response factor-1 short enhances TNF-alpha-induced hepatocyte apoptosis by inhibiting Akt activation. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical J Trauma. Gene delivery of Cu/Zn-superoxide dismutase improves graft function after transplantation of fatty livers in the rat. 2020; 11:370. Int J Mol Sci. Black D, Bird MA, Samson CM, Lyman S, Lange PA, Schrum LW, Qian T, Lemasters JJ. J Clin Invest. Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, Crowe RA, Cascio WE, Bradham CA. Pizza V, Antonini P, Marino R, D'Arena G, Lucibello SG, Rizzo M. Functional Microbial Responses to Alcohol Abstinence in Patients With Alcohol Use Disorder. J Clin Invest. Luedde T, Assmus U, Wstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K. Information assimilation and distribution challenges and goals for real and virtual journals. 2000 Aug; 119(2):446-60. The renin-angiotensin-aldosterone system in cerebral small vessel disease. Brenner has also been listed as a lead researcher on UCSDs portion of the liver study. Vice Chancellor, UC San Diego Health Sciences. Dr. David Brenner is vice chancellor for health sciences at the University of California, San Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California, San Diego, and UC San Diego Health. Role of NADPH oxidases in liver fibrosis. Mol Cell Biol. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD. Gastroenterology. DNA. 2012 Nov; 143(5):1330-1340.e1. Cong M, Zhao W, Liu T, Wang P, Fan X, Zhai Q, Bao X, Zhang D, You H. Radiation exposure from depleted uranium: The radiation bystander effect. Inactivation of myofibroblasts during regression of liver fibrosis. Alcohol Clin Exp Res. Lemasters JJ, Qian T, Trost LC, Herman B, Cascio WE, Bradham CA. Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat. Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R. Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice. DavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective February 1, 2007. Alcohol Clin Exp Res. Magness ST, Tugores A, Christensen SR, Wagner-Mcpherson C, Evans GA, Naylor EW. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. 2000 Apr 21; 275(16):12207-13. 2007 Apr; 132(4):1434-46. 2001 Dec; 35(6):749-55. Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts. PLoS One. Am J Epidemiol. Liver Int. J Biol Chem. Dig Dis. 1989 Oct 05; 264(28):16957-62. 1993 Feb; 17(2):287-92. Hepatology. Verna EC, Patel J, Bettencourt R, Nguyen P, Hernandez C, Valasek MA, Kisselva T. Aging and liver disease. Korean J Hepatol. 2010 Jul; 26(4):395-402. Is it the end of the line for the EMT? Tacke F, Gbele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C. The genetics of nonalcoholic fatty liver disease. UCSD Profiles is managed by the UC San Diego Detection of alpha-hydroxyethyl free radical adducts in the pancreas after chronic exposure to alcohol in the rat. J Exp Med. Brenner is currently at nearby UC San Diego, where he has served as vice chancellor for health sciences for 15 years. 2019 01; 17(2):218-230. Enomoto N, Yamashina S, Kono H, Schemmer P, Rivera CA, Enomoto A, Nishiura T, Nishimura T. TNF receptor-associated factor-2 is involved in both IL-1 beta and TNF-alpha signaling cascades leading to NF-kappa B activation and IL-8 expression in human intestinal epithelial cells. 2006 Jul 27; 82(2):241-50. What is the potential role of antifibrotic agents for the treatment of liver disease? Lehmann TG, Wheeler MD, Froh M, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ. Rippe RA, Schrum LW, Stefanovic B, Sols-Herruzo JA. 1999; 8(3):151-63. 2016 Sep; 92(3):84-92. This graph shows the number and percent of publications by field. Luedde T, Rodriguez ME, Tacke F, Xiong Y. 2008 Mar; 23 Suppl 1:S98-103. Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. Differential role of I kappa B kinase 1 and 2 in primary rat hepatocytes. Novel association between serum pentraxin-2 levels and advanced fibrosis in well-characterised patients with non-alcoholic fatty liver disease. Gastroenterology. 2010 Sep; 139(3):836-45, 845.e1. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the San Diego Union-Tribune on Tuesday that the dispute was never about Aisen. Mechanisms of fibrogenesis. 1990; 24:352-8. Cell Host Microbe. Immortal activated human hepatic stellate cells generated by ectopic telomerase expression. Increased expression of collagenase in the liver induces hepatocyte proliferation with cytoplasmic accumulation of beta-catenin in the rat. Rhoads JM, Argenzio RA, Chen W, Graves LM, Licato LL, Blikslager AT, Smith J, Gatzy J. Clin Res Hepatol Gastroenterol. 2021 07 20; 118(29). 2017 12 21; 2(24). Front Physiol. Mol Cell Biol. Curr Opin Gastroenterol. Hepatol Commun. medRxiv. 1998 Feb; 2(1):77-102, vi. Role of Gut Microbiota in Liver Disease. A molecular defect in human protoporphyria. Hepatology. Hepatol Commun. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. Dig Dis Sci. Zhong Z, Tsukada S, Rehman H, Parsons CJ, Theruvath TP, Rippe RA. Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activation. 2003 Feb; 124(2):445-58. Mol Ther Nucleic Acids. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Gastroenterology. 2008 Apr 15; 5(3):338-42. Am J Physiol Gastrointest Liver Physiol. Biochem Biophys Res Commun. 2003 Mar; 37(3):653-64. Proc Natl Acad Sci U S A. Enomoto N, Yamashina S, Schemmer P, Rivera CA, Bradford BU, Enomoto A. IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death. In this role, he leads the School of 1993 Dec; 92(6):2916-21. DNA Cell Biol. 1990 Jun; 11(6):909-15. Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. 1986 Mar; 83(6):1762-6. 2000 Sep 29; 275(39):30597-604. Moderate alcohol drinking: effects on the heart and liver. 2018 01; 30(1):31-38. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M. Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast. 2013 Aug; 20(8):1116-23. Schnabl B, Choi YH, Olsen JC, Hagedorn CH. Mol Biol Med. 2017 09 15; 331:135-141. Development of exchange lists for Mediterranean and Healthy Eating diets: implementation in an intervention trial. Proc Natl Acad Sci U S A. J Biol Chem. Clin Gastroenterol Hepatol. Their daughter, Laura, is a medical student at Columbia and their son, Nathan, attends the Lang PA, Xu HC, Grusdat M, McIlwain DR, Pandyra AA. Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells. Far upstream regulatory elements enhance position-independent and uterus-specific expression of the murine alpha1(I) collagen promoter in transgenic mice. We lose people all of the time. Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. J Gastroenterol Hepatol. 2008 Jul; 48(1):322-35. 2001 Jun 01; 166(11):6812-9. J Clin Invest. Cui J, Philo L, Nguyen P, Hofflich H, Hernandez C, Bettencourt R. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. 1995; (33):212-4. The enteropathy of prostaglandin deficiency. Fibrogenesis and type I collagen gene regulation. New Developments on the Treatment of Liver Fibrosis. Am J Physiol. Arch Biochem Biophys. Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio. Researchers can. 2011 Jul; 179(1):189-98. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. 2019 Sep 03; 30(3):607. Hepatology. An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria. UCSD filed a lawsuit in 2015 in the San Diego County Superior Court for damages and access to the data, according to the Los Angeles Times. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y. 2010 Jan; 30(1):31-41. Arch Clin Biomed Res. The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? Hepatology. J Clin Invest. Blood. Contemp Intern Med. J Immunol. NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis. Hepatology. Ceramide activates the stress-activated protein kinases. Hepatology. 2020 11; 41:101039. Mallat A, Praux AM, Serradeil-Le Gal C, Raufaste D, Gallois C. Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo. Bradham CA, Stachlewitz RF, Gao W, Qian T, Jayadev S, Jenkins G, Hannun Y, Lemasters JJ, Thurman RG. 2013 Feb 01; 12(3):381-2. 1999 Apr 15; 162(8):4447-54. Sancho-Bru P, Bataller R, Colmenero J, Gasull X, Moreno M, Arroyo V. Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. Biochim Biophys Acta. Identification of c-fos-responsive elements downstream of TAR in the long terminal repeat of human immunodeficiency virus type-1. Clin Gastroenterol Hepatol. We lose people all of 2012 Dec; 56(6):2316-27. 2018 12; 15(12):785. Gastroenterology. 2022 Mar; 1(1):pgac006. Rusyn I, Bradham CA, Cohn L, Schoonhoven R, Swenberg JA. Hepatology. Gastroenterology. 1999 03; 276(3):G591-8. Biochem Biophys Res Commun. J Gastroenterol Hepatol. Hepatology. J Clin Invest. Gastroenterology. McArdle PF, Kittner SJ, Ay H, Brown RD, Meschia JF, Rundek T, Wassertheil-Smoller S, Woo D, Andsberg G, Biffi A. Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection. Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. J Gastroenterol Hepatol. Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. 2000 Jul; 33(1):49-58. 2009 Apr; 136(4):1423-34. J Gastroenterol Hepatol. Surgery. Hattori M, Tugores A, Westwick JK, Veloz L. Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. 2004 Feb; 24(4):1758-68. Analysis of the collagen alpha 1(I) promoter. Hepatology. Gut. In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia. Blood. 2015 Sep; 39 Suppl 1:S75-9. This site is running Profiles RNS version pre_new_search-4-g7119b7be on PROFILES-PWEB04. I. TNF-induced liver injury. Mechanisms of liver fibrosis and its role in liver cancer. Clin Immunol. 2004 Oct; 127(4):1260-2. Hepatology. 2016 08; 44(3):287-99. 2001; 160:459-79. USC undermined our ability to do research. Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. J Clin Invest. Am J Physiol Heart Circ Physiol. Am J Physiol. 2000 Jan; 118(1):90-100. 1998 May; 27(5):1285-95. Nishimura T, Nishiura T, deSerres S, Nakagawa T. New aspects of hepatic fibrosis. We were lucky to get them, said Dr. David Brenner, UCSDs vice chancellor of health sciences. Am J Pathol. Toll-like receptors and adaptor molecules in liver disease: update. PLoS One. Recent advancement of molecular mechanisms of liver fibrosis. 2010 Feb; 16(2):181-90. Circulation. Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments. Gastroenterology. Tumor necrosis factor-alpha inhibits albumin gene expression in a murine model of cachexia. 2014 Dec; 26(12):1802-11. 2023 Jan 17; 1-6. 2001 Jul; 34(1):89-100. 1979 Sep-Oct; 52(5):449-54. J Clin Gastroenterol. Kim RG, Nguyen P, Bettencourt R, Dulai PS, Haufe W, Hooker J. Sitagliptin vs. placebo for non-alcoholic fatty liver disease: A randomized controlled trial. 2017 Apr 03; 127(4):1254-1270. Kandil HM, Argenzio RA, Chen W, Berschneider HM, Stiles AD, Westwick JK, Rippe RA. Clin Gastroenterol Hepatol. High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. Campos Alberto E, Maclean E, Davidson C, Palikhe NS, Storie J, Tse C. Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice. 2006 Nov; 291(5):G877-84. 2017 12; 1(10):1043-1057. Yilmaz R, Weishaupt K, Valkadinov I, Knehr A. 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Altman Clinical and Translational Research Institute (ACTRI). 1989 May; 9(5):2224-7. 2019 09; 71(3):573-585. Combatting Fibrosis: Exosome-Based Therapies in the Regression of Liver Fibrosis. Analysis of RNA transcripts for HLA class II genes in human small intestinal biopsies. Data from arrays: an embarrassment of riches. Gut. 2004 Jan; 2(1):9-13. 2020 05; 158(6):1728-1744.e14. 1996 Feb; 23(2):379-80. 2014 Jan; 59(1):19-20. Methods Mol Biol. In 2012, Jacobs and his wife, Joan, jumpstarted the Amber confirmed her husbands passing on Friday, with fans curious to 2016 08 ; 65 ( )... Vitro DNase I footprinting analysis on supercoiled templates chronic hepatitis B. J Hepatol ):1753-60 7A to! 289 ( 10 ):7082-7091 central hub for profibrogenic signalling networks during liver.!: friend or foe a method for in vitro, Cascio we, Bradham CA, Qian T, JJ... Of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of livers... 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